Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
USERS' SCORE
Good
Based on 35 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Aquamin®)
80 mg
6%
UC-II® Standardized Chicken Cartilage(Providing 10 mg Total Collagen, including Undenatured Type II Collagen)
40 mg
†
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)
250 mg
†
Top Medical Research Studies
9
We explored the effects of decoction (GSZD) on bone erosion linked to rheumatoid arthritis (RA) in a rat model. Our study involved various groups receiving either GSZD or standard treatments, monitoring changes in paw volume and arthritic severity.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
Read More
8
We investigated the efficacy of a petroleum ether extract from the hips of Rosa multiflora in treating collagen-induced arthritis in rats. The study used a control group, treated with various doses of the extract, and compared it against a well-known medication.
The results showed that the highest dose effectively reduced arthritis severity and paw swelling. It also appeared to inhibit inflammation markers and boost antioxidant enzyme levels. However, the precise mechanisms of how the extract works and its key components need further research.
The results showed that the highest dose effectively reduced arthritis severity and paw swelling. It also appeared to inhibit inflammation markers and boost antioxidant enzyme levels. However, the precise mechanisms of how the extract works and its key components need further research.
Read More
8
We assessed the effects of collagen supplements, specifically strain CCFM1074, on arthritis in rats. This study utilized a robust method that examined the immune responses, gut microbiota, and various metabolites.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Read More
Most Useful Reviews
9
Therapeutic effect
27 people found this helpful
While marketed for cartilage strengthening, I utilise it for "relapsed polychondritis," an autoimmune disorder I've suffered from for six years. This disorder is caused by collagen type 2 producing autoantibodies. I've proven that UC-II acts therapeutically with my body, and I am nearly fully recovered but take it daily for prevention.
Read More
9
Parents feel great
9 people found this helpful
Great collagen for joints and more! I ordered it with glucosamine and hyaluronic acid to support my parents' joint health. Prior to this, my mother had taken collagen types 1 and 3. Since starting this supplement, they've experienced no side effects and are very pleased with the improvement; their stiffness has vanished and they feel fantastic!
Read More
9
Highly effective
6 people found this helpful
I have suffered from knee degeneration for years and tried many glucosamine and collagen supplements. None have been as effective as Now Food UC-II. I will definitely re-order this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
- All Researches
9
We explored how the collagen supplement BD400 affects rheumatoid arthritis (RA) using a collagen-induced arthritis rat model.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
Read More
9
We explored the effects of decoction (GSZD) on bone erosion linked to rheumatoid arthritis (RA) in a rat model. Our study involved various groups receiving either GSZD or standard treatments, monitoring changes in paw volume and arthritic severity.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
Read More
8
We assessed the effects of collagen supplements, specifically strain CCFM1074, on arthritis in rats. This study utilized a robust method that examined the immune responses, gut microbiota, and various metabolites.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Read More
8
We examined the anti-inflammatory properties of liposome/gold hybrid nanoparticles that contain Coenzyme Q10 (LGNP-CoQ10) in a model of rheumatoid arthritis in mice. Over 10 weeks, we treated the mice with LGNP-CoQ10 and noted that it significantly reduced inflammation and levels of specific pro-inflammatory factors.
Moreover, the treatment showed a decrease in pro-inflammatory cell populations, indicating a reduced inflammatory response that could benefit those suffering from rheumatoid arthritis. Our findings highlight the promising therapeutic potential of LGNP-CoQ10 in managing inflammatory autoimmune disorders.
Moreover, the treatment showed a decrease in pro-inflammatory cell populations, indicating a reduced inflammatory response that could benefit those suffering from rheumatoid arthritis. Our findings highlight the promising therapeutic potential of LGNP-CoQ10 in managing inflammatory autoimmune disorders.
Read More
8
We explored how Hsp65, a protein delivered by beneficial bacteria, can help prevent arthritis in mice. In our study, continuous delivery in the gut led to the creation of regulatory T cells that successfully blocked the onset of arthritis. We observed reduced clinical signs of arthritis and lower inflammation markers, like IL-17 and anti-collagen antibodies. This approach appears to modify gut bacteria and enhance immune tolerance, suggesting Hsp65 could potentially be a new tool for treating autoimmune diseases.
Read More
User Reviews
USERS' SCORE
Good
Based on 35 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Therapeutic effect
27 people found this helpful
While marketed for cartilage strengthening, I utilise it for "relapsed polychondritis," an autoimmune disorder I've suffered from for six years. This disorder is caused by collagen type 2 producing autoantibodies. I've proven that UC-II acts therapeutically with my body, and I am nearly fully recovered but take it daily for prevention.
Read More
9
Parents feel great
9 people found this helpful
Great collagen for joints and more! I ordered it with glucosamine and hyaluronic acid to support my parents' joint health. Prior to this, my mother had taken collagen types 1 and 3. Since starting this supplement, they've experienced no side effects and are very pleased with the improvement; their stiffness has vanished and they feel fantastic!
Read More
9
Highly effective
6 people found this helpful
I have suffered from knee degeneration for years and tried many glucosamine and collagen supplements. None have been as effective as Now Food UC-II. I will definitely re-order this product.
Read More
9
Improved running
3 people found this helpful
Excellent product! I was an elite middle-distance runner but struggled since I turned 40. I had noticeable creaking in my knees, especially when going up and down stairs. After trying various supplements, I started taking this collagen almost two years ago. Within a month, the creaking ceased, and my running gait is much improved. Although I'm not as fast as before, I'm certainly enjoying running again.
Read More
9
Elasticity and relief
2 people found this helpful
I am ordering for the second time. Initially persuaded by a friend, I experienced remarkable results by the end of the first course—I felt as if I were jumping with agility! My joints gained elasticity, stopped cracking, and the painful knee discomfort diminished in cold weather. After a year, I decided to repeat the course. I noted no discomfort during use, and the effects seem to accumulate over time. My co-workers, inspired by my experience, have also chosen to order this product. I highly recommend it!
Read More
Frequently Asked Questions
7.5
Joint improvement visible
3 people found this helpful
The joints have stopped cracking! After two weeks of using the product, my MCH noted a significant decrease in joint noise. While it’s premature to determine its overall effectiveness, there is already an observable improvement! We've also added effervescent vitamin C to enhance collagen absorption, which may facilitate quicker results.
9
Elasticity and relief
2 people found this helpful
I am ordering for the second time. Initially persuaded by a friend, I experienced remarkable results by the end of the first course—I felt as if I were jumping with agility! My joints gained elasticity, stopped cracking, and the painful knee discomfort diminished in cold weather. After a year, I decided to repeat the course. I noted no discomfort during use, and the effects seem to accumulate over time. My co-workers, inspired by my experience, have also chosen to order this product. I highly recommend it!
9
Hip joint pain relief
1 people found this helpful
I order for my husband, not for the first time, as it lasts about four months. He experiences pain in his hip joints, and after the first four months of taking collagen type 2 with vitamin C as prescribed by his doctor, the pain vanished. He now takes it periodically for prevention. It worked perfectly.
9
Therapeutic effect
27 people found this helpful
While marketed for cartilage strengthening, I utilise it for "relapsed polychondritis," an autoimmune disorder I've suffered from for six years. This disorder is caused by collagen type 2 producing autoantibodies. I've proven that UC-II acts therapeutically with my body, and I am nearly fully recovered but take it daily for prevention.
9
Crunch disappeared
1 people found this helpful
Great! The joint crunching stopped. Previously, sudden movements caused a crackle in my joints. After a month of taking this, the crunch has completely vanished. I will order more.
9
Parents feel great
9 people found this helpful
Great collagen for joints and more! I ordered it with glucosamine and hyaluronic acid to support my parents' joint health. Prior to this, my mother had taken collagen types 1 and 3. Since starting this supplement, they've experienced no side effects and are very pleased with the improvement; their stiffness has vanished and they feel fantastic!
9
Improved running
3 people found this helpful
Excellent product! I was an elite middle-distance runner but struggled since I turned 40. I had noticeable creaking in my knees, especially when going up and down stairs. After trying various supplements, I started taking this collagen almost two years ago. Within a month, the creaking ceased, and my running gait is much improved. Although I'm not as fast as before, I'm certainly enjoying running again.
7.5
Hiking now possible
1 people found this helpful
Effective! I've taken this product to address my knee degenerative arthritis pain, and I'm now able to go hiking again. I plan to order more for myself as well as for friends and family. Its value in comparison with similar domestic UC-II health products is notably higher!
7.5
Significant improvement
2 people found this helpful
This supplement was recommended by my nutritionist as the best option. After taking it in combination with other medications, I have experienced significant improvements. I will surely order more, following my doctor's advice to take it in courses.
9
Autoimmunity reduced
NOW Foods, UC-II, 60 Veg Capsules. UC-II Type 2 Collagen delivers Type 2 Collagen at a therapeutic dose, contributing to reduced autoimmunity towards the body's own collagen. This results in decreased inflammation linked to autoimmune disorders such as RA and OA, thus benefiting joint health. Studies in Japan showed that the effects last for 30 days; hence, a monthly course is advisable. This preparation contains Aquamin, a marine multi-mineral which is effective against inflammation and enhances joint mobility in osteoarthritis, potentially reducing the need for non-steroidal anti-inflammatory drugs.
9
We explored how the collagen supplement BD400 affects rheumatoid arthritis (RA) using a collagen-induced arthritis rat model.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
8
We assessed the effects of collagen supplements, specifically strain CCFM1074, on arthritis in rats. This study utilized a robust method that examined the immune responses, gut microbiota, and various metabolites.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
8
We investigated the efficacy of a petroleum ether extract from the hips of Rosa multiflora in treating collagen-induced arthritis in rats. The study used a control group, treated with various doses of the extract, and compared it against a well-known medication.
The results showed that the highest dose effectively reduced arthritis severity and paw swelling. It also appeared to inhibit inflammation markers and boost antioxidant enzyme levels. However, the precise mechanisms of how the extract works and its key components need further research.
The results showed that the highest dose effectively reduced arthritis severity and paw swelling. It also appeared to inhibit inflammation markers and boost antioxidant enzyme levels. However, the precise mechanisms of how the extract works and its key components need further research.
8
Probiotic sugar aids arthritis treatment
We examined whether the exopolysaccharide (EPS) from Lactobacillus rhamnosus could help manage arthritis in mice. By injecting a collagen mix to trigger arthritis, we measured how EPS affected antibody production and disease severity.
Our findings showed that EPS significantly lowered the specific antibodies related to arthritis and eased symptoms in active models of collagen-induced arthritis. However, its benefits were less noticeable in severe cases with high antibody levels. Overall, EPS shows promise as a supportive treatment for rheumatoid arthritis in humans.
Our findings showed that EPS significantly lowered the specific antibodies related to arthritis and eased symptoms in active models of collagen-induced arthritis. However, its benefits were less noticeable in severe cases with high antibody levels. Overall, EPS shows promise as a supportive treatment for rheumatoid arthritis in humans.
References
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. 10.3389/fimmu.2025.1518181
- Fan Z, Ross RP, Stanton C, Hou B, Zhao J, et al. CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota. Front Immunol. 2021;12:680073. 10.3389/fimmu.2021.680073
- Wei SJ, Zhang Q, Xiang YJ, Peng LY, Peng W, et al. decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis. Pharm Biol. 2021;59:262. 10.1080/13880209.2021.1876100
- Jhun J, Moon J, Ryu J, Shin Y, Lee S, et al. Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting. PLoS One. 2020;15:e0241080. 10.1371/journal.pone.0241080
- Gusmao-Silva G, Aguiar SLF, Miranda MCG, Guimarães MA, Alves JL, et al. Hsp65-Producing Prevents Antigen-Induced Arthritis in Mice. Front Immunol. 2020;11:562905. 10.3389/fimmu.2020.562905
- Wu J, Liu X, Chan CO, Mok DK, Chan SW, et al. Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats. J Ethnopharmacol. 2014;157:45. 10.1016/j.jep.2014.09.026
- Nowak B, Ciszek-Lenda M, Sróttek M, Gamian A, Kontny E, et al. Lactobacillus rhamnosus exopolysaccharide ameliorates arthritis induced by the systemic injection of collagen and lipopolysaccharide in DBA/1 mice. Arch Immunol Ther Exp (Warsz). 2012;60:211. 10.1007/s00005-012-0170-5
